Overview

Auerbachstraße 112, 70376 Stuttgart, Deutschland
Vollzeit
Tätigkeitsfeld: Wissenschaft & Forschung
Beschäftigungsumfang: Vollzeit

Unternehmensbeschreibung

The Robert Bosch Center for Tumor Diseases (RBCT) is a newly founded translational cancer research institute located on the Bosch Health Campus in Stuttgart, Germany in direct proximity to the Robert Bosch Hospital (RBK) and the Institute for Clinical Pharmacology (IKP). The RBCT is also part of the Comprehensive Cancer Center Stuttgart-Tübingen. Our goal is to elucidate the molecular mechanisms driving tumor growth and metastasis as well as identify the key determinants of therapy resistance and sensitivity mainly in pancreatic, colorectal and lung cancer with the aim of improving patient treatment. The major focus of our work is on regulation of cellular identity through transcriptional and epigenetic mechanisms and relies in part on the generation and analysis of high-throughput -omics data.  With this aim, we are looking for a talented and motivated bioinformatics specialist to join our RBCT Team and support us in cutting-edge bioinformatics, statistics, and data-mining methods in order to assist statistical interpretation of the data and hypothesis generation. We will provide a dynamic, international and stimulating scientific environment in which the candidate will have the opportunity to improve his/her scientific knowledge and computational skills and contribute to relevant research publications.

Stellenbeschreibung

Implement bioinformatics and statistical analyses of next-generation sequencing data (e.g. bulk and single cell RNA-Seq, DNA methylation, ChIP-Seq, HiC, ATAC-Seq, etc.)
Develop and maintain pipelines for processing multiple types of next generation sequencing (NGS) data
Work closely with wet bench researchers to support data exploration and experimental design
Summarize and communicate analysis results effectively, help driving conclusions
Work in close collaboration with IT specialist to manage and maintain necessary software
Provide workshops on relevant topics

Qualifikationen

M.Sc and/or Ph.D. in bioinformatics, computational biology, statistics, or related field.
Experience with data analysis and visualization and very good level of statistics
Experience in Bash, R, and Python (Perl and/or C / C++ is a plus)
Broad experience with NGS and other omics technologies while being focused on biological questions (knowledge about cancer biology & -omics is a plus)
Proficiency with computer hardware and software including different operating system environments (such as Mac, Windows and UNIX) and High Performance Computing (HPC) clusters, schedulers and tools
Modern software benchmarking, deployment (Conda), and version control (Git)
Workflow management (Snakemake) and documentation (jupyter notebooks). Knowledge in laboratory information management system (LIMS) is considered as a strong plus
Strong programming skills and experience in algorithm development (using Python, C++, Java). Experience with analytics on big data sets is a plus.
Knowledge in machine learning methods, such as predictive modeling, mixed-effect models, multivariate analysis, etc. is considered a strong plus
Ability to work both independently and collaboratively, and to handle several projects
Strong communication skills and good command of the English language (knowledge of German is a plus, but not essential).
Strong problem-solving and collaboration skills and rigorous and creative thinking

Zusätzliche Informationen

If we have awoken your interest, please upload your CV, cover letter and list of three references.

Contact is Steven A. Johnsen, Ph.D. ([email protected]). 

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