The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Division of Cancer Epigenomics at the German Cancer Research Center is offering a
Group Leader Position in Computational Epigenomics
The Division of Cancer Epigenomics is part of the Research Program on Functional and Structural Genomics with close interactions with experts in genome analysis, metabolism, proteomics, chromatin biology and computational genomics. The division has a translational science focus to generate new knowledge on the contributions of epigenomic mechanisms to cancer development, thereby contributing to improved therapy options and patient survival. Division members participate in large national and international consortia on lung cancer ( www.dzl.de ), prostate cancer ( www.panprostate.org ) and acute myeloid leukemia ( www.uni-ulm.de/en/einrichtungen/sfb-1074 ).
Applications are invited for a group leader position in the Division of Cancer Epigenomics ( www.dkfz.de/en/CanEpi/ ) headed by Prof. Dr. Christoph Plass, an internationally renowned expert in cancer epigenomics with more than 30 years of expertise in the field. The group will lead research on Computational Epigenomics, based on large data sets characterizing transcription, nucleosome positioning, 3D chromatin architecture, DNA methylation, histone modifications and from single-cell and spatial technologies, and will support Professor Plass in the smooth running of the laboratory at various levels. Research in the Division of Cancer Epigenomics employs cutting-edge epigenetics and molecular biology tools in combination with genomics and computational biology approaches to develop comprehensive concepts for epigenome-wide misregulation of gene expression during the development of cancer and therapy resistance and its involvement in DNA repair defects.
The group will be part of a greater initiative to develop a Computational Epigenomics Hub to support epigenetic research at the German Cancer Research Center and will closely interact with the computational groups for Applied Bioinformatics (Prof. Dr. Benedikt Brors: www.dkfz.de/en/applied-bioinformatics ) and Computational Genomics and Systems Genetics (Prof. Dr. Oliver Stegle: www.dkfz.de/en/bioinformatik-genomik-systemgenetik ).
For further information please see selected recent publications:
Nat. Commun. 2022, 13: 4557; Nat. Commun. 2022, 13: 2042 ; Nat. Commun. 2021, 12: 6520; Nucleic Acids Res. 2021, 49: 11666-11689; Sci. Transl. Med. 2021, 13: eabc4834; Nat. Commun. 2020, 11: 5414; Nat. Protoc. 2020, 15: 3240-3263; Genome Med. 2020, 12: 29; Nature 2020, 578: 82-93; Cancer Cell 2018, 34: 996-1011; Nat. Immunol. 2017, 18: 1160-1172; Nat. Genet. 2017, 49: 1052-1060; Nat. Biotechnol. 2016, 34: 726-37; Nat. Genet. 2016, 48: 253-64; Nat. Genet. 2015, 47: 22-30; Cancer Discov. 2014, 4: 348-61.
Establish and lead the Group for Computational Epigenomics in the Division of Cancer Epigenomics
Design research projects and establish innovative computational methods and bioinformatical tools to solve epigenomic research questions
Support division members in basic and translational science projects
Conduct collaborative research and interact with a broad range of colleagues and researchers
Apply for research funding either alone or in collaboration with other group leaders in the division or at the German Cancer Research Center
Maintain the bioinformatics infrastructure within the division
Support the division head in everyday routines including training of new group members
Collaborate with internal and external partners
Contribute to teaching in the Master Program on Cancer Biology ( www.dkfz.de/en/major-cancer-biology )
PhD in computational biology and/or bioinformatics and not more than three years of postdoctoral experience
Excellent track record in omics data analysis and integration
Familiarity with epigenomics research and oncology is mandatory
Interest in working in a multidisciplinary and multicultural team
Willing to collaborate with internal and external collaborators as well as support group members
Experience and interest in teaching
Fluent in English and basic knowledge of German
Interesting, versatile workplace
International, attractive working environment
Campus with modern state-of-the-art infrastructure
Salary according to TV-L including social benefits
Possibility to work part-time
Flexible working hours
Comprehensive further training program
The position is limited to 3 years with the possibility of prolongation.
The position can in principle be part-time.
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
For further information please contact
Prof. Dr. Christoph Plass, phone +49 (0)6221/42-3300.
The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.
Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
To apply for a position please use our online application portal ( www.dkfz.de ).
We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.
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Heidelberg 69120 Im Neuenheimer Feld 280